It has been ascertained that the human brain is a complex system studied at multiple scales,
from neurons and microcircuits to macronetworks. The brain is characterized by a …

Introduction: Ocular manifestations in several neurological pathologies accentuate the
strong relationship between the eye and the brain. Retinal alterations in particular can serve …

Background Although cerebral small-vessel disease has been implicated in the
development of Alzheimer's disease (AD), the cerebral microcirculation is difficult to …

PURPOSE: To examine the influence of a range of cardiovascular risk factors and ocular
conditions on retinal vascular fractal dimension in the Singapore Malay Eye Study. DESIGN …

Introduction Cerebral Small Vessel Disease (CSVD), a progressive degenerative disorder of
small caliber cerebral vessels, represents a major contributor to stroke and vascular …

Background and aims We aimed to comprehensively describe a spectrum of retinal vessel
measures including fractal dimension (D f) and their associations with indices of coronary …

The retinal circulation is a potential marker of cerebral vascular disease because it shares
origin and drainage with the intracranial circulation and because it can be directly visualized …

Novel retinal imaging techniques have enabled the assessment of quantitative vascular
parameters, which provide information on the microvasculature before the appearance of …

Fractal analysis is a method used to quantify the geometric branching complexity and
density of retinal vessels. This study examined the relationship of retinal vascular fractal …

Although cerebral small vessel disease has been implicated in the development of
Alzheimer's disease (AD), the cerebral microcirculation is difficult to visualize directly in vivo …