The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities
It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …
Neuronal networks in hypertension: recent advances
PG Guyenet, RL Stornetta, GMPR Souza… - …, 2020 - Am Heart Assoc
Neurogenic hypertension is associated with excessive sympathetic nerve activity to the
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
kidneys and portions of the cardiovascular system. Here we examine the brain regions that …
Purinergic receptors in the carotid body as a new drug target for controlling hypertension
W Pijacka, DJA Moraes, LEK Ratcliffe… - Nature medicine, 2016 - nature.com
In view of the high proportion of individuals with resistance to antihypertensive medication
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …
Cardiorespiratory interactions in humans and animals: rhythms for life
M Elstad, EL O'Callaghan, AJ Smith… - American Journal …, 2018 - journals.physiology.org
The cardiorespiratory system exhibits oscillations from a range of sources. One of the most
studied oscillations is heart rate variability, which is thought to be beneficial and can serve …
studied oscillations is heart rate variability, which is thought to be beneficial and can serve …
GLP1R attenuates sympathetic response to high glucose via carotid body inhibition
Background: Aberrant sympathetic nerve activity exacerbates cardiovascular risk in
hypertension and diabetes, which are common comorbidities, yet clinically sympathetic …
hypertension and diabetes, which are common comorbidities, yet clinically sympathetic …
Respiratory–cardiovascular interactions
Much of biology is rhythmical and comprises oscillators that can couple. These have
optimized energy efficiency and have been preserved during evolution. The respiratory and …
optimized energy efficiency and have been preserved during evolution. The respiratory and …
Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years
Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …
Simultaneous assessment of central and peripheral chemoreflex regulation of muscle sympathetic nerve activity and ventilation in healthy young men
Key points Central chemoreceptor stimulation, by hypercapnia (acidosis), and peripheral, by
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
hypoxia plus hypercapnia, evoke reflex increases in ventilation and sympathetic outflow …
Rostral ventrolateral medulla and hypertension
PG Guyenet, RL Stornetta, BB Holloway… - …, 2018 - Am Heart Assoc
560 Hypertension September 2018 of interest in the potential contribution of sympatho-
respiratory coupling to SNA elevation in neurogenic hypertension. As summarized below …
respiratory coupling to SNA elevation in neurogenic hypertension. As summarized below …
Computational models of the neural control of breathing
The ongoing process of breathing underlies the gas exchange essential for mammalian life.
Each respiratory cycle ensues from the activity of rhythmic neural circuits in the brainstem …
Each respiratory cycle ensues from the activity of rhythmic neural circuits in the brainstem …