[HTML][HTML] Cellular toxicity and immunological effects of carbon-based nanomaterials

X Yuan, X Zhang, L Sun, Y Wei, X Wei - Particle and fibre toxicology, 2019 - Springer
Background Carbon nanomaterials are a growing family of materials featuring unique
physicochemical properties, and their widespread application is accompanied by increasing …

[HTML][HTML] Functionalised carbon nanotubes: From intracellular uptake and cell-related toxicity to systemic brain delivery

PM Costa, M Bourgognon, JTW Wang… - Journal of Controlled …, 2016 - Elsevier
Carbon nanotubes (CNTs) have long been regarded as promising carriers in biomedicine.
Due to their high surface area and unique needle-like structure, CNTs are uniquely …

Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells

H Chen, Y Lu, Z Cao, Q Ma, H Pi, Y Fang, Z Yu, H Hu… - Toxicology letters, 2016 - Elsevier
Cadmium (Cd) is an important and common environmental pollutant that has been linked to
cardiovascular diseases, such as atherosclerosis and hypertension. Increasing evidence …

[HTML][HTML] Effect of MWCNT size, carboxylation, and purification on in vitro and in vivo toxicity, inflammation and lung pathology

RF Hamilton, Z Wu, S Mitra, PK Shaw… - Particle and fibre toxicology, 2013 - Springer
Background Several properties of multi-walled carbon nanotubes (MWCNT) have the
potential to affect their bioactivity. This study examined the in vitro and in vivo outcomes of …

The asbestos-carbon nanotube analogy: An update

AB Kane, RH Hurt, H Gao - Toxicology and applied pharmacology, 2018 - Elsevier
Nanotechnology is an emerging industry based on commercialization of materials with one
or more dimensions of 100 nm or less. Engineered nanomaterials are currently incorporated …

The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury

HD Jones, TR Crother… - American journal of …, 2014 - atsjournals.org
IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute
respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) …

Nanomaterials and innate immunity: a perspective of the current status in nanosafety

JG Cronin, N Jones, CA Thornton… - Chemical Research …, 2020 - ACS Publications
Human exposure to engineered nanomaterials (ENMs) is inevitable due to the plethora of
applications for which they are being manufactured and integrated within. ENMs …

A multi-stakeholder perspective on the use of alternative test strategies for nanomaterial safety assessment

AE Nel, E Nasser, H Godwin, D Avery, T Bahadori… - ACS …, 2013 - ACS Publications
There has been a conceptual shift in toxicological studies from describing what happens to
explaining how the adverse outcome occurs, thereby enabling a deeper and improved …

Nanomaterial-based scaffolds for bone tissue engineering and regeneration

G Ye, F Bao, X Zhang, Z Song, Y Liao, Y Fei… - …, 2020 - Taylor & Francis
The global incidence of bone tissue injuries has been increasing rapidly in recent years,
making it imperative to develop suitable bone grafts for facilitating bone tissue regeneration …

Phagolysosome acidification is required for silica and engineered nanoparticle-induced lysosome membrane permeabilization and resultant NLRP3 inflammasome …

F Jessop, RF Hamilton Jr, JF Rhoderick… - Toxicology and Applied …, 2017 - Elsevier
NLRP3 inflammasome activation occurs in response to hazardous particle exposures and is
critical for the development of particle-induced lung disease. Mechanisms of Lysosome …