Nutrigenomics, the microbiome, and gene-environment interactions: new directions in cardiovascular disease research, prevention, and treatment: a scientific …

JF Ferguson, H Allayee, RE Gerszten… - Circulation …, 2016 - Am Heart Assoc
Cardiometabolic diseases are the leading cause of death worldwide and are strongly linked
to both genetic and nutritional factors. The field of nutrigenomics encompasses multiple …

[HTML][HTML] Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity

X Wang, Q Cao, L Yu, H Shi, B Xue, H Shi - JCI insight, 2016 - ncbi.nlm.nih.gov
Obesity is associated with increased classically activated M1 adipose tissue macrophages
(ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity …

High fat diet drives obesity regardless the composition of gut microbiota in mice

S Rabot, M Membrez, F Blancher, B Berger, D Moine… - Scientific reports, 2016 - nature.com
The gut microbiota is involved in many aspects of host physiology but its role in body weight
and glucose metabolism remains unclear. Here we studied the compositional changes of …

Dynamic transcriptome and DNA methylome analyses on longissimus dorsi to identify genes underlying intramuscular fat content in pigs

Y Wang, C Ma, Y Sun, Y Li, L Kang, Y Jiang - BMC genomics, 2017 - Springer
Background The intramuscular fat content (IMF) refers to the amount of fat within muscles,
including the sum of phospholipids mainly found in cell membranes, triglycerides and …

Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression

SB Sonne, R Yadav, G Yin, MD Dalgaard, LS Myrmel… - Adipocyte, 2017 - Taylor & Francis
The present study aimed to identify genes exhibiting concomitant obesity-dependent
changes in DNA methylation and gene expression in adipose tissues in the mouse using …

Methylation of apoptosis-associated speck-like protein with a caspase recruitment domain and outcomes in heart failure

B Butts, RA Gary, SB Dunbar, J Butler - Journal of cardiac failure, 2016 - Elsevier
Background Heart failure (HF) is associated with inflammation characterized by the
formation of the inflammasome, which triggers maturation of inflammatory cytokines …

Analysis of Tks4 knockout mice suggests a role for Tks4 in adipose tissue homeostasis in the context of beigeing

V Vas, T Háhner, G Kudlik, D Ernszt, K Kvell, D Kuti… - Cells, 2019 - mdpi.com
Obesity and adipocyte malfunction are related to and arise as consequences of
disturbances in signaling pathways. Tyrosine kinase substrate with four Src homology 3 …

Identification of DNA methylation prognostic signature of acute myelocytic leukemia

H Zhang, G Song, G Song, R Li, M Gao, L Ye… - PLoS One, 2018 - journals.plos.org
Background The aim of this study is to find the potential survival related DNA methylation
signature capable of predicting survival time for acute myelocytic leukemia (AML) patients …

Profiling of N6-methyladenosine methylation in porcine longissimus dorsi muscle and unravelling the hub gene ADIPOQ promotes adipogenesis in an m6A …

H Gong, T Gong, Y Liu, Y Wang, X Wang - Journal of Animal Science and …, 2023 - Springer
Background Intramuscular fat (IMF) content is a critical indicator of pork quality, and
abnormal IMF is also relevant to human disease as well as aging. Although N6 …

Evaluation of leptin and MMP2 genes methylation in childhood obesity

S El Sayed, E Khairy, AR Basheer, WS Zaki, GF Ahmad… - Gene Reports, 2018 - Elsevier
Recent novel eras of research are opening for the effective management of obesity, in
general and childhood obesity, in specific through gene and nutrient intake interactions …