Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …
The latest developments in imaging of fibroblast activation protein
A Altmann, U Haberkorn, J Siveke - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
Fibroblast activation protein (FAP), a membrane-anchored peptidase, is highly expressed in
cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to …
cancer-associated fibroblasts in more than 90% of epithelial tumors and contributes to …
Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer
Purpose We evaluated the potential usefulness of [68 Ga] Ga-DOTA-FAPI-04 positron
emission tomography/computed tomography (PET/CT) for the diagnosis of primary and …
emission tomography/computed tomography (PET/CT) for the diagnosis of primary and …
[HTML][HTML] FAPI-74 PET/CT using either 18F-AlF or cold-kit 68Ga labeling: biodistribution, radiation dosimetry, and tumor delineation in lung cancer patients
68 Ga-fibroblast activation protein inhibitors (FAPIs) 2, 4, and 46 have already been
proposed as promising PET tracers. However, the short half-life of 68 Ga (68 min) creates …
proposed as promising PET tracers. However, the short half-life of 68 Ga (68 min) creates …
[HTML][HTML] Head-to-head intra-individual comparison of biodistribution and tumor uptake of 68Ga-FAPI and 18F-FDG PET/CT in cancer patients
FL Giesel, C Kratochwil, J Schlittenhardt… - European journal of …, 2021 - Springer
Purpose FAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for
PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The …
PET/CT imaging, demonstrated in previous studies rapid and high tumor uptake. The …
Initial clinical experience with 90Y-FAPI-46 radioligand therapy for advanced-stage solid tumors: a case series of 9 patients
J Ferdinandus, PF Costa, L Kessler… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in several solid tumors and therefore
represents an attractive target for radiotheranostic applications. Recent investigations …
represents an attractive target for radiotheranostic applications. Recent investigations …
[HTML][HTML] 68Ga-FAPI-PET/CT in patients with various gynecological malignancies
K Dendl, SA Koerber, R Finck, KMG Mokoala… - European journal of …, 2021 - Springer
Purpose 68Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising
radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the …
radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the …
[HTML][HTML] FAPI-PET/CT in cancer imaging: a potential novel molecule of the century
R Huang, Y Pu, S Huang, C Yang, F Yang, Y Pu… - Frontiers in …, 2022 - frontiersin.org
Fibroblast activation protein (FAP), a type II transmembrane serine protease, is highly
expressed in more than 90% of epithelial tumors and is closely associated with various …
expressed in more than 90% of epithelial tumors and is closely associated with various …
[HTML][HTML] Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model
Y Liu, T Watabe, K Kaneda-Nakashima… - European Journal of …, 2022 - Springer
Purpose Fibroblast activation protein (FAP), which has high expression in cancer-associated
fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study …
fibroblasts of epithelial cancers, can be used as a theranostic target. Our previous study …
Biodistribution, pharmacokinetics, dosimetry of [68Ga]Ga-DOTA.SA.FAPi, and the head-to-head comparison with [18F]F-FDG PET/CT in patients with various cancers
Abstract Purpose [68 Ga] Ga-labeled fibroblast activation protein inhibitors ([68 Ga] Ga-FAPi)
have shown promising preclinical and clinical results in PET imaging. The present study …
have shown promising preclinical and clinical results in PET imaging. The present study …