[HTML][HTML] The role of platelets in immune-mediated inflammatory diseases

M Scherlinger, C Richez, GC Tsokos… - Nature Reviews …, 2023 - nature.com
Immune-mediated inflammatory diseases (IMIDs) are characterized by excessive and
uncontrolled inflammation and thrombosis, both of which are responsible for organ damage …

[HTML][HTML] Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation

J Zindel, P Kubes - Annual Review of Pathology: Mechanisms of …, 2020 - annualreviews.org
Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

[HTML][HTML] Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Circulating platelets as mediators of immunity, inflammation, and thrombosis

M Koupenova, L Clancy, HA Corkrey… - Circulation …, 2018 - Am Heart Assoc
Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

The immune nature of platelets revisited

A Maouia, J Rebetz, R Kapur, JW Semple - Transfusion medicine reviews, 2020 - Elsevier
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints
them with a variety of inflammatory processes. For example, platelets can act as circulating …

[HTML][HTML] Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP)

A Zufferey, R Kapur, JW Semple - Journal of clinical medicine, 2017 - mdpi.com
Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

[HTML][HTML] Platelets as key factors in inflammation: focus on CD40L/CD40

F Cognasse, AC Duchez, E Audoux… - Frontiers in …, 2022 - frontiersin.org
Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …

[HTML][HTML] Platelets in sepsis: an update on experimental models and clinical data

A Assinger, WC Schrottmaier, M Salzmann… - Frontiers in …, 2019 - frontiersin.org
Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …