The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …

Macrophage activation/polarization to distinct functional states is critically supported by
metabolic shifts. How polarizing signals coordinate metabolic and functional …

The eosinophil-derived neurotoxin (EDN/RNase2) and its divergent orthologs, the mouse
eosinophil-associated RNases (mEars), are prominent secretory proteins of eosinophilic …

The Ribonuclease A Superfamily is composed of cationic peptides that are secreted by
immune cells and epithelial tissues. Although their physiological roles are unclear, several …

Enzyme superfamily members that share common chemical and/or biological functions also
share common features. While the role of structure is well characterized, the link between …

The human ribonuclease A (hRNase A) superfamily is comprised of 13 members of
secretory RNases, most of which are recognized as catabolic enzymes for their …

Extracellular vesicles (EVs) are increasingly appreciated as important vectors of information
transmission between cells. Most research on EVs has emphasized their roles in …

Eosinophil numbers are highly elevated during helminth infections and a range of allergic
and inflammatory disorders, but eosinophils are also present in several tissues in the …

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, has been recently associated
with the development of autoimmune diseases, including systemic lupus erythematosus …

Synchrotron microbeam radiation treatment (MRT) is a preclinical radiotherapy technique
with considerable clinical promise, although some of the underlying radiobiology of MRT is …