Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …

The rise of bacterial resistance to current antibiotics poses a threat to humanity and
reinforces the need for new-generation nanomaterials with antibacterial properties and …

Intense efforts to detect, diagnose, and analyze the kinetic and structural properties of
amyloid fibrils have generated a powerful toolkit of amyloid-specific molecular probes. Since …

Spider silk is strong and extensible but still biodegradable and well tolerated when
implanted, making it the ultimate biomaterial. Shortcomings that arise in replicating spider …

Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …

FoldX is an empirical force field that was developed for the rapid evaluation of the effect of
mutations on the stability, folding and dynamics of proteins and nucleic acids. The core …

Enzymatic activity is crucial for various technological applications, yet the complex structures
and limited stability of enzymes often hinder their use. Hence, de novo design of robust …