In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …

The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …

Transcription and pre-mRNA splicing are key steps in the control of gene expression and
mutations in genes regulating each of these processes are common in leukaemia,. Despite …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …

Abstract RNA polymerase II (RNAPII) pausing/termination shortly after initiation is a hallmark
of gene regulation. Here, we show that negative elongation factor (NELF) interacts with …

The DNA damage response (DDR) is brought about by a protein kinase cascade that
orchestrates DNA repair through transcriptional and posttranslational mechanisms. Cell …