Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …

From historical studies of developing chick hearts to recent advances in regenerative injury
models, the epicardium has arisen as a key player in heart genesis and repair. The …

Neonatal mice have been shown to regenerate their hearts during a transient window of
time of approximately 1 week after birth. However, experimental evidence for this …

Ischemic heart disease is a leading cause of death worldwide. After the onset of myocardial
infarction, many pathological changes take place and progress the disease towards heart …

The molecular mechanisms that drive mammalian cardiomyocytes out of the cell cycle soon
after birth remain largely unknown. Here, we identify telomere dysfunction as a critical …

In mammals, proliferative capacity of cardiomyocytes is lost soon after birth, while zebrafish
and other lower organisms like newts are known to regenerate injured hearts even at an …

Ventricular chamber growth and development during perinatal circulatory transition is critical
for functional adaptation of the heart. However, the chamber-specific programs of neonatal …

Cardiovascular diseases are the number one cause of death worldwide and in the United
States (US). Cardiovascular diseases frequently progress to end-stage heart failure, and …

78 Circulation July 14, 2015 mammalian heart to regenerate and the subsequent loss of this
ability provide an important tool for studying the aspects of regeneration that are not a part of …

Cardiomyocytes are critically responsible for heart contraction and the pumping of blood
through the circulatory system. In adult mice and humans, the rate of cardiomyocyte division …