Microfluidic single-cell manipulation and analysis: Methods and applications

T Luo, L Fan, R Zhu, D Sun - Micromachines, 2019 - mdpi.com
In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Electrokinetic motion of particles and cells in microchannels

Y Kang, D Li - Microfluidics and nanofluidics, 2009 - Springer
This paper provides an overview of the electrokinetic phenomena associated with particles
and cells in microchannel systems. The most important phenomena covered include …

Visualization and measurements of blood cells flowing in microfluidic systems and blood rheology: A personalized medicine perspective

D Pinho, V Carvalho, IM Gonçalves, S Teixeira… - Journal of Personalized …, 2020 - mdpi.com
Hemorheological alterations in the majority of metabolic diseases are always connected
with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell …

Microfluidic device embedding electrodes for dielectrophoretic manipulation of cells‐A review

J Yao, G Zhu, T Zhao, M Takei - Electrophoresis, 2019 - Wiley Online Library
Microfluidic device embedding electrodes realizes cell manipulation with the help of
dielectrophoresis. Cell manipulation is an important technology for cell sorting and cell …

Microfluidic single-cell analysis of intracellular compounds

TC Chao, A Ros - Journal of the Royal Society Interface, 2008 - royalsocietypublishing.org
Biological analyses traditionally probe cell ensembles in the range of 103–106 cells, thereby
completely averaging over relevant individual cell responses, such as differences in cell …

Glucose and lactate miniaturized biosensors for SECM-based high-spatial resolution analysis: a comparative study

A Soldà, G Valenti, M Marcaccio, M Giorgio… - ACS …, 2017 - ACS Publications
With the aim of developing miniaturized enzymatic biosensors suitable for in vitro diagnostic
applications, such as monitoring of metabolites at single cell level, glucose and lactate …

Electric and electrochemical microfluidic devices for cell analysis

K Hiramoto, K Ino, Y Nashimoto, K Ito, H Shiku - Frontiers in chemistry, 2019 - frontiersin.org
Microfluidic devices are widely used for cell analysis, including applications for single-cell
analysis, healthcare, environmental monitoring, and organs-on-a-chip that mimic organs in …

Electrochemical single-cell gene-expression assay combining dielectrophoretic manipulation with secreted alkaline phosphatase reporter system

T Murata, T Yasukawa, H Shiku, T Matsue - Biosensors and Bioelectronics, 2009 - Elsevier
Scanning electrochemical microscopy (SECM) was used for the analysis of single-cell gene-
expression signals on the basis of a reporter system. We microfabricated a single-cell array …

Dynamic electrochemical control of cell capture-and-release based on redox-controlled host–guest interactions

T Gao, L Li, B Wang, J Zhi, Y Xiang, G Li - Analytical chemistry, 2016 - ACS Publications
Artificial control of cell adhesion on smart surface is an on-demand technique in areas
ranging from tissue engineering, stem cell differentiation, to the design of cell-based …

Electrochemical Gene‐Function Analysis for Single Cells with Addressable Microelectrode/Microwell Arrays

Z Lin, Y Takahashi, T Murata, M Takeda… - Angewandte Chemie …, 2009 - Wiley Online Library
To each his own: An addressable electrochemical device consisting of orthogonally
arranged rows and columns of electrodes has been constructed to monitor protein …