The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …

Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Objective To incorporate recent research findings, expert consensus, and patient
perspectives into updated guidance on the use of new acute and preventive treatments for …

Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …

Migraine is a common, disabling neurological disorder characterized by multiple phases:
premonitory, aura, headache, postdrome, and interictal. Our understanding of the …

Objective To provide healthcare professionals with updated guidance in the use of novel
preventive and acute treatments for migraine in adults. Background The principles of …

Migraine is a common, multifactorial, disabling, recurrent, hereditary neurovascular
headache disorder. It usually strikes sufferers a few times per year in childhood and then …

Importance Migraine is the second leading cause of disability worldwide. Most patients with
migraine discontinue medications due to inefficacy or adverse effects. Mindfulness-based …

Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one
of the most common sequelae of mild traumatic brain injury, also known as concussion …

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and
synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central …