The underlying role of inflammation in atherosclerosis has been characterized. However,
current treatment of coronary artery disease (CAD) predominantly consists of targeted …

Serine protease inhibitors, SERPINS, are a highly conserved family of proteins that regulate
serine proteases in the central coagulation and immune pathways, representing 2–10% of …

Myxomatosis is a lethal disease in wild European and domestic rabbits (Oryctolagus
cuniculus), which is caused by a Myxoma virus (MYXV) infection—a leporipoxvirus that is …

Non-targeted persistent immune activation or suppression by different drug delivery
platforms can cause adverse and chronic physiological effects including cancer and arthritis …

Immunopathogenesis in systemic viral infections can induce a septic state with leaky
capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment …

Spinal cord injury (SCI) results in massive secondary damage characterized by a prolonged
inflammation with phagocytic macrophage invasion and tissue destruction. In prior work …

Serpins regulate coagulation and inflammation, binding serine proteases in suicide-
inhibitory complexes. Target proteases cleave the serpin reactive center loop scissile P1 …

The identification of molecules from various pathogens that modulate innate and/or adaptive
immunity is a dynamic and rapidly developing area of research. These immunomodulatory …

Viruses are widely used as a platform for the production of therapeutics. Vaccines containing
live, dead and components of viruses, gene therapy vectors and oncolytic viruses are key …

Diffuse alveolar hemorrhage (DAH) is one of the most serious clinical complications of
systemic lupus erythematosus (SLE). The prevalence of DAH is reported to range from 1 to …