Pathophysiology of fibrosis in the vocal fold: current research, future treatment strategies, and obstacles to restoring vocal fold pliability

Y Kumai - International journal of molecular sciences, 2019 - mdpi.com
Communication by voice depends on symmetrical vibrations within the vocal folds (VFs) and
is indispensable for various occupations. VF scarring is one of the main reasons for …

Stem cell approaches for vocal fold regeneration

JM Fishman, J Long, M Gugatschka… - The …, 2016 - Wiley Online Library
Objectives/Hypothesis Current interventions in the management of vocal fold (VF)
dysfunction focus on conservative and surgical approaches. However, the complex structure …

Predictors of posterior glottic stenosis: a multi-institutional case-control study

AT Hillel, S Karatayli-Ozgursoy… - Annals of Otology …, 2016 - journals.sagepub.com
Objective: To assess intrinsic and extrinsic risk factors in the development of posterior glottic
stenosis (PGS) in intubated patients. Methods: Patients diagnosed with PGS between …

Concurrent YAP/TAZ and SMAD signaling mediate vocal fold fibrosis

R Nakamura, N Hiwatashi, R Bing, CP Doyle… - Scientific Reports, 2021 - nature.com
Vocal fold (VF) fibrosis is a major cause of intractable voice-related disability and reduced
quality of life. Excision of fibrotic regions is suboptimal and associated with scar recurrence …

Mesenchymal stem cells have antifibrotic effects on transforming growth factor‐β1‐stimulated vocal fold fibroblasts

N Hiwatashi, R Bing, I Kraja, RC Branski - The Laryngoscope, 2017 - Wiley Online Library
Objectives/Hypothesis Mesenchymal stem cells (MSCs) hold therapeutic promise for vocal
fold scar, yet the precise mechanism (s) underlying tissue level changes remain unclear. We …

Metabolic variations in normal and fibrotic human laryngotracheal‐derived fibroblasts: a Warburg‐like effect

G Ma, I Samad, K Motz, LX Yin, MV Duvvuri… - The …, 2017 - Wiley Online Library
Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a chronic fibrotic disease
characterized by fibroblast proliferation, collagen deposition, and matrix remodeling in the …

Current practices for voice rest recommendations after phonomicrosurgery

A Joshi, MM Johns III - The Laryngoscope, 2018 - Wiley Online Library
Objectives/Hypothesis The aim of this study was to understand current protocols for voice
rest implemented by laryngologists immediately after phonomicrosurgery for benign vocal …

In vitro evaluation of anti‐fibrotic effects of select cytokines for vocal fold scar treatment

H Chen, J Erndt‐Marino… - … Research Part B …, 2019 - Wiley Online Library
Scarring of the vocal fold lamina propria (LP) can cause considerable voice disorders due to
reduced pliability in scar tissue, attributed in part to abnormal extracellular matrix (ECM) …

An in vitro assessment of the response of THP‐1 macrophages to varying stiffness of a glycol‐chitosan hydrogel for vocal fold tissue engineering applications

PT Coburn, AC Herbay, M Berrini… - Journal of Biomedical …, 2021 - Wiley Online Library
The physical properties of a biomaterial play an essential role in regulating immune and
reparative activities within the host tissue. This study aimed to evaluate the immunological …

The efficacy of a novel collagen–gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar

N Hiwatashi, S Hirano, M Mizuta… - Journal of tissue …, 2017 - Wiley Online Library
Vocal fold scar remains a therapeutic challenge. Basic fibroblast growth factor (bFGF) was
reported to have regenerative effects for vocal fold scar, although it has the disadvantage of …