The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Wound healing is a well-tuned biological process, which is achieved via consecutive and
overlapping phases including hemostasis, inflammatory-related events, cell proliferation and …

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …

Heme oxygenases (HOs) act on heme degradation to produce carbon monoxide (CO), free
iron, ferritin, and biliverdin. Upregulation of cellular HO-1 levels is signature of oxidative …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

Background Diabetic foot ulcer (DFU), one of the diabetic complications, brings high burden
to diabetic patients. Hyperbaric oxygen therapy (HBOT) has been proven to be an effective …

Mesenchymal stem cells (MSCs) protect tissues against cell death induced by
ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological …

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

A large percentage of the population suffers from wound healing abnormalities, in particular
aged individuals, patients with diabetes, and those treated with immunosuppressive drugs …

Since skin is the first barrier separating the body from the external environment, impaired
wound healing can be life threatening to living organisms. Delayed healing processes are …