Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Open-shell molecules such as radicals, carbenes, and electronically excited-state molecules
exhibit high energies, and thus, in general, they are quite reactive. 1 The short-lived species …

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive
species are reviewed. A short introduction summarizes the basic reactivities of aryne …

1. INTRODUCTION Within 14 years of the seminal experiments of JD Roberts leading to the
first proposal of the structure of benzyne (1), 1 synthetic organic chemists recognized the …

Recent developments in aryne chemistry are reviewed with a particular focus on synthetic
methods. This includes an overview of the precursors of arynes and their activators; the …

N-Heterocyclic carbene (NHC) organocatalysis has emerged as a powerful tool in the field
of modern organic synthesis especially in asymmetric construction of various cyclic …

Ortho-quinone methides are important synthetic intermediates and widely implicated in
biological processes. In this Synopsis, recent advances concerning the synthesis and utility …

This Feature Article is aimed at highlighting the recent developments in the transition-metal-
free molecular rearrangements involving arynes. The chemistry of arynes has shown …

Arynes hold significance for the efficient fusion of (hetero) arenes with diverse substrates,
advancing the construction of complex molecular frameworks. Employing multiple …

Aromatic units are common scaffolds in bioactive molecules, natural products, and polymer
materials. The catalytic functionalization of aromatic sp2 carbon atoms and attached …