Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid
cells that have potent immune-suppressive activity. Studies in both mice and humans have …

Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for
the treatment of hematological malignancies. However, in patients with solid tumors …

Objective Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to
facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive …

Despite progress in the development of drugs that efficiently target cancer cells, treatments
for metastatic tumours are often ineffective. The now well-established dependency of cancer …

Distinct tumor microenvironment forms in each progression step of cancer and has diverse
capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now …

Background & Aims Neutrophils can either promote or inhibit tumor progression, depending
on the tumor microenvironment, via release of cytokines. Neither the factors produced by …

The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …

Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …