BRD4 and Cancer: going beyond transcriptional regulation
B Donati, E Lorenzini, A Ciarrocchi - Molecular cancer, 2018 - Springer
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
Adipogenesis: a complex interplay of multiple molecular determinants and pathways
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem …
Transcriptional and epigenomic regulation of adipogenesis
Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …
[HTML][HTML] BRD4 orchestrates genome folding to promote neural crest differentiation
Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies …
mediating genome folding underlie developmental disorders known as cohesinopathies …
Targeting bromodomain and extraterminal proteins for drug discovery: from current progress to technological development
P Tang, J Zhang, J Liu, CM Chiang… - Journal of medicinal …, 2021 - ACS Publications
Bromodomain and extraterminal (BET) proteins bind acetylated lysine residues in histones
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …
and nonhistone proteins via tandem bromodomains and regulate chromatin dynamics …
[HTML][HTML] Opposing functions of BRD4 isoforms in breast cancer
Summary Bromodomain-containing protein 4 (BRD4) is a cancer therapeutic target in
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …
ongoing clinical trials disrupting primarily BRD4-regulated transcription programs. The role …
[HTML][HTML] RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation
The bromodomain and extra-terminal motif (BET) protein BRD4 binds to acetylated histones
at enhancers and promoters via its bromodomains (BDs) to regulate transcriptional …
at enhancers and promoters via its bromodomains (BDs) to regulate transcriptional …
Inhibitors of bromodomain and extra‐terminal proteins for treating multiple human diseases
E Kulikowski, BD Rakai… - Medicinal research …, 2021 - Wiley Online Library
Clinical development of bromodomain and extra‐terminal (BET) protein inhibitors differs
from the traditional course of drug development. These drugs are simultaneously being …
from the traditional course of drug development. These drugs are simultaneously being …
Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury
The endogenous repair process can result in recovery after acute kidney injury (AKI) with
adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and …
adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and …
A chemical toolbox for the study of bromodomains and epigenetic signaling
Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …