Bone Morphogenetic Proteins (BMPs) play an important role during organ development and
during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine …

Neural induction represents the earliest step in the determination of ectodermal cell fates. In
vertebrates, bone morphogenetic proteins (BMPs) act as signals of epidermal induction. The …

High-throughput mapping of cellular differentiation hierarchies from single-cell data
promises to empower systematic interrogations of vertebrate development and disease …

The sequencing of the zebrafish genome should be completed by the end of 2002. Direct
assignment of function on the basis of this information would be facilitated by the …

Embryonic patterning in vertebrates is dependent upon the balance of inductive signals and
their specific antagonists. We show that Noggin, which encodes a bone morphogenetic …

The signals directing primordial germ cell (PGC) migration in vertebrates are largely
unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are …

Current methods for comparing single-cell RNA sequencing datasets collected in multiple
conditions focus on discrete regions of the transcriptional state space, such as clusters of …

▪ Abstract We review the current status of research in dorsal-ventral (DV) patterning in
vertebrates. Emphasis is placed on recent work on Xenopus, which provides a paradigm for …

The transforming growth factor-β (TGF-β) superfamily contains a variety of growth factors
which all share common sequence elements and structural motifs. These proteins are …

Despite the bewildering number of cell types and patterns found in the animal kingdom, only
a few signalling pathways are required to generate them. Most cell–cell interactions during …