Fibrosis–a debilitating condition that can occur in most organs–is characterized by excess
deposition of a collagen-rich extracellular matrix (ECM). At first sight, the activities of …

There is an unmet need for high‐quality liquid biomarkers that can safely and reproducibly
predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The …

Articular cartilage is a connective tissue consisting of a specialized extracellular matrix
(ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are …

Interstitial fibrosis is the common endpoint of end-stage chronic kidney disease (CKD)
leading to kidney failure. The clinical course of many renal diseases, and thereby of CKD, is …

Adipocytes represent a major cell type in the mammary tumor microenvironment and are
important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue …

Several collagen subtypes have been identified in hyaline articular cartilage. The main and
most abundant collagens are type II, IX and XI collagens. The minor and less abundant …

Different stimulants might induce different extracellular matrix profiles. It is essential to gain
an understanding and quantification of these changes to allow for focused anti-fibrotic drug …

Increased attention is paid to the structural components of tissues. These components are
mostly collagens and various proteoglycans. Emerging evidence suggests that altered …

Cancer‐associated fibroblasts (CAFs) deposit and remodel collagens in the tumor stroma,
impacting cancer progression and efficacy of interventions. CAFs are the focus of new …

The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …