T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …

Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …

Chimeric antigen receptor–modified T cells with specificity for CD19 have shown promise in
the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether …

B-cell acute lymphoblastic leukemia (B-ALL) is the commonest childhood cancer and the
prognosis of children with relapsed or therapy refractory disease remains a challenge …

The most common cause of treatment failure in childhood acute lymphoblastic leukemia
(ALL) remains relapse, occurring in∼ 15%-20% of patients. Survival of relapsed patients …

Background and Methods It is uncertain whether mortality rates among patients who have
undergone bone marrow transplantation return to the level of the mortality rates of the …

T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype of acute lymphoblastic
leukemia (ALL) with gradually improved survival through introduction of intensified …

The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is
diagnosed in approximately 2000 children in the United States each year, whereas acute …

Purpose Approximately 20% of children with acute lymphoblastic leukemia (ALL) suffer a
relapse, and their prognosis is unfavorable. Between 1987 and 1990, the multicenter trial …

The treatment of acute leukaemias, which are the most common paediatric cancers, has
improved considerably in recent decades, with complete response rates approaching∼ …