Opportunities and challenges of the tag-assisted protein purification techniques: Applications in the pharmaceutical industry

MM Gomari, N Saraygord-Afshari, M Farsimadan… - Biotechnology …, 2020 - Elsevier
Tag-assisted protein purification is a method of choice for both academic researches and
large-scale industrial demands. Application of the purification tags in the protein production …

[HTML][HTML] A critical review on human malaria and schistosomiasis vaccines: current state, recent advancements, and developments

AJ Siddiqui, J Bhardwaj, J Saxena, S Jahan, M Snoussi… - Vaccines, 2023 - mdpi.com
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …

Vaccines and monoclonal antibodies: new tools for malaria control

K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

[HTML][HTML] Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development

BN Kanoi, H Nagaoka, M Morita, T Tsuboi… - Parasitology …, 2021 - Elsevier
Vaccines against infectious diseases have had great successes in the history of public
health. Major breakthroughs have occurred in the development of vaccine-based …

First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN (K3)

S Ezoe, NMQ Palacpac, K Tetsutani, K Yamamoto… - Vaccine, 2020 - Elsevier
Background BK-SE36 is blood-stage malaria vaccine candidate that is undergoing clinical
trials. Here, the safety and immunogenicity of BK-SE36 with a novel adjuvant, CpG-ODN …

[HTML][HTML] Malaria vaccines: facing unknowns

NMQ Palacpac, T Horii - F1000Research, 2020 - ncbi.nlm.nih.gov
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …

[HTML][HTML] In silico characterisation of putative Plasmodium falciparum vaccine candidates in African malaria populations

O Ajibola, MF Diop, A Ghansah, L Amenga-Etego… - Scientific reports, 2021 - nature.com
Genetic diversity of surface exposed and stage specific Plasmodium falciparum
immunogenic proteins pose a major roadblock to developing an effective malaria vaccine …

[HTML][HTML] A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies

E Takashima, H Nagaoka, R Correia, PM Alves… - Frontiers in …, 2022 - frontiersin.org
PfRipr is a highly conserved asexual-blood stage malaria vaccine candidate against
Plasmodium falciparum. PfRipr5, a protein fragment of PfRipr inducing the most potent …

[HTML][HTML] Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults

FD Partey, JNN Dowuona, ANA Pobee, MR Walker… - Scientific Reports, 2024 - nature.com
Clinical immunity to malaria develops slowly after repeated episodes of infection and
antibodies are essential in naturally acquired immunity against malaria. However, chronic …

[HTML][HTML] The Cellular and Molecular Interaction Between Erythrocytes and Plasmodium falciparum Merozoites

J Molina-Franky, ME Patarroyo, M Kalkum… - Frontiers in cellular …, 2022 - frontiersin.org
Plasmodium falciparum is the most lethal human malaria parasite, partly due to its genetic
variability and ability to use multiple invasion routes via its binding to host cell surface …