Detecting biothreat agents: From current diagnostics to developing sensor technologies

SA Walper, G Lasarte Aragonés, KE Sapsford… - ACS …, 2018 - ACS Publications
Although a fundamental understanding of the pathogenicity of most biothreat agents has
been elucidated and available treatments have increased substantially over the past …

Ricinus communis Intoxications in Human and Veterinary Medicine—A Summary of Real Cases

S Worbs, K Köhler, D Pauly, MA Avondet, M Schaer… - Toxins, 2011 - mdpi.com
Accidental and intended Ricinus communis intoxications in humans and animals have been
known for centuries but the causative agent remained elusive until 1888 when Stillmark …

Forensic proteomics

GJ Parker, HE McKiernan, KM Legg… - Forensic Science …, 2021 - Elsevier
Protein is a major component of all biological evidence, often the matrix that embeds other
biomolecules such as polynucleotides, lipids, carbohydrates, and small molecules. The …

[HTML][HTML] Ricin detection: tracking active toxin

WP Bozza, WH Tolleson, LAR Rosado, B Zhang - Biotechnology advances, 2015 - Elsevier
Ricin is a plant toxin with high bioterrorism potential due to its natural abundance and
potency in inducing cell death. Early detection of the active toxin is essential for developing …

Proteomic methods of detection and quantification of protein toxins

M Duracova, J Klimentova, A Fucikova, J Dresler - Toxins, 2018 - mdpi.com
Biological toxins are a heterogeneous group of compounds that share commonalities with
biological and chemical agents. Among them, protein toxins represent a considerable …

Medical Countermeasures against ricin intoxication

C Rasetti-Escargueil, A Avril - Toxins, 2023 - mdpi.com
Ricin toxin is a disulfide-linked glycoprotein (AB toxin) comprising one enzymatic A chain
(RTA) and one cell-binding B chain (RTB) contained in the castor bean, a Ricinus species …

Multiplex quantification of protein toxins in human biofluids and food matrices using immunoextraction and high-resolution targeted mass spectrometry

M Dupré, B Gilquin, F Fenaille… - Analytical …, 2015 - ACS Publications
The development of rapid methods for unambiguous identification and precise quantification
of protein toxins in various matrices is essential for public health surveillance. Nowadays …

Characterization of Ricin and R. communis Agglutinin Reference Materials

S Worbs, M Skiba, M Söderström, ML Rapinoja… - Toxins, 2015 - mdpi.com
Ricinus communis intoxications have been known for centuries and were attributed to the
toxic protein ricin. Due to its toxicity, availability, ease of preparation, and the lack of medical …

Multiplex detection of protein toxins using MALDI-TOF-TOF tandem mass spectrometry: application in unambiguous toxin detection from bioaerosol

SI Alam, B Kumar, DV Kamboj - Analytical chemistry, 2012 - ACS Publications
Protein toxins, such as botulinum neurotoxins (BoNTs), Clostridium perfringens epsilon toxin
(ETX), staphylococcal enterotoxin B (SEB), shiga toxin (STX), and plant toxin ricin, are …

A single DNA aptamer functions as a biosensor for ricin

EA Lamont, L He, K Warriner, TP Labuza, S Sreevatsan - Analyst, 2011 - pubs.rsc.org
The use of microorganisms or toxins as weapons of death and fear is not a novel concept;
however, the modes by which these agents of bioterrorism are deployed are increasingly …