Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Caspase-3 plays irreplaceable roles in apoptosis and related diseases. An imbalance in the
measured levels of Caspase-3 is implicated in irreversible apoptosis. Therefore, the …

Surgical resection of tumours requires precisely locating and defining the margins between
lesions and normal tissue. However, this is made difficult by irregular margin borders …

Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …

As a result of their high specificity for their corresponding biological targets, peptides have
shown significant potential in a range of diagnostic and therapeutic applications. However …

A fluorescent probe based on an excimer-forming benzothiazolyl-cyanovinylene (CV) dye
was developed to target the apoptotic protease caspase-3. Upon the action of caspase-3 …

Successful treatment of cancer patients requires balancing of the dose, timing, and type of
therapeutic regimen. Detection of increased cell death may serve as a predictor of the …

Proteases are involved in a wide variety of biologically and medically important events. They
are entangled in a complex network of processes that regulate their activity, which makes …

Caspases are an important protease family that coordinate inflammation and programmed
cell death. Two closely related caspases, caspase-3 and caspase-7, exhibit largely …