ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Alzheimer's disease (AD), the most common neurodegenerative disorder, is the leading
cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …

The Abl Family Kinases: Mechanisms of Regulation and Signaling Page 1 The Abl Family
Kinases: Mechanisms of Regulation and Signaling Ann Marie Pendergast Department of …

The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …

Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by
ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced …

Altered amyloid precursor protein (APP) processing leading to increased production and
oligomerization of Aβ may contribute to Alzheimer's disease (AD). Understanding how APP …

The amyloid precursor protein (APP) is a transmembrane protein that plays major roles in
the regulation of several important cellular functions, especially in the nervous system …

The mechanisms regulating the outgrowth of neurites during development, as well as after
injury, are key to the understanding of the wiring and functioning of the brain under normal …