Since the discovery of leucine-rich repeat kinase 2 (LRRK2) as a protein that is likely central
to the aetiology of Parkinson's disease, a considerable amount of work has gone into …

The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

Mutations associated with leucine-rich repeat kinase 2 are the most common known cause
of Parkinson's disease. The known expression of leucine-rich repeat kinase 2 in immune …

Mutations in the LRRK2 gene represent the most common genetic cause of late onset
Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully …

Mutations in the leucine‐rich repeat kinase 2 (LRRK 2)‐encoding gene are the most
common cause of monogenic Parkinson's disease. The identification of LRRK 2 …

Missense mutations in the multi-domain kinase LRRK2 cause late onset familial Parkinson's
disease. They most commonly with classic proteinopathy in the form of Lewy bodies and …

Cytoskeletal homeostasis is essential for the development, survival and maintenance of an
efficient nervous system. Microtubules are highly dynamic polymers important for neuronal …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset autosomal
dominant Parkinson's disease (PD), and sequence variations at the LRRK2 locus are …

The roles of Wnts in neural development, synaptogenesis, and cancer are generally well
characterized. Nonetheless, evidence exists that interactions between the immune and …

Mitochondria have been largely described as the powerhouse of the cell and recent findings
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …