Iron, an essential nutrient, is required for many diverse biological processes. The absence of
a defined pathway to excrete excess iron makes it essential for the body to regulate the …

Iron holds a central position at the host–pathogen interface because mammalian and
microbial cells have an essential demand for the metal, which is required for many metabolic …

Iron and immunity are closely linked: firstly by the fact that many of the genes/proteins
involved in iron homoeostasis play a vital role in controlling iron fluxes such that bacteria are …

Background Visceral leishmaniasis (VL) could progress to secondary hemophagocytic
lymphohistiocytosis (HLH), which is a rare but life-threatening condition with poor prognosis …

Highlights•Mammalian transferrin maintains iron homeostasis in serum and extracellular
tissue fluid.•Sequestration of iron is an innate host strategy to prevent pathogenic microbial …

Over 2 billion people in both developing as well as developed countries–over 30% of the
world's population–are anaemic. With the classical preconception that oral iron …

The anaemia of chronic disease (ACD) results from inflammation-mediated up-regulation of
the iron regulatory hormone hepcidin, with the consequent sequestration of iron limiting its …

Iron metabolism and erythropoiesis are inherently interlinked physiological processes.
Regulation of iron metabolism is mediated by the iron‐regulatory hormone hepcidin …

Effective erythropoiesis requires an appropriate supply of iron and mechanisms regulating
iron homeostasis and erythropoiesis are intrinsically linked. Iron dysregulation, typified by …

BMP-SMAD signalling plays a crucial role in numerous biological processes including
embryonic development and iron homeostasis. Dysregulation of the iron-regulatory …