Concepts regarding the mechanisms by which drugs activate receptors to produce
physiological response have progressed beyond considering the re¬ ceptor as a simple on …

This article describes the expected phenotypic behavior of all types of ligands in
constitutively active receptor systems and, in particular, the molecular mechanisms of …

The vulnerability of neurons and the irreversibility of loss make discoveries of
neuroprotective compounds fundamentally important. Here, the complete coding sequence …

We have cloned and sequenced a cDNA (RPR4) encoding a new member of the
secretin/calcitonin/parathyroid hormone (PTH) receptor family. RPR4 was identified by PCR …

We have recently cloned the mouse activity-dependent neuroprotective protein (ADNP).
Here, we disclose the cloning of human ADNP (hADNP) from a fetal brain cDNA library …

FACTORS controlling central nervous system (CNS) growth immediately after neurulation
are mostly unknown. Vasoactive intestinal peptide (VIP) receptors are widely distributed in …

A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting
neuroprotection at unprecedented concentrations, is revealed. This peptide prevented …

Neurodegenerative diseases, in which neuronal cell disintegrate, bring about deteriorations
in cognitive functions as is evidenced in millions of Alzheimer patients. A major …

Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is
neuroprotective at femtomolar concentrations. A nine-amino acid peptide derived from …

Gourlet, P., P. De Neef, J. Cnudde, M. Waelbroeck and P. Robberecht. In vitro properties of a
high affinity selective antagonist of the VIP1 receptor. Peptides 18 (10) 1555–1560, 1997 …