The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

The defining entity of a selenoprotein is the inclusion of at least one selenocysteine (Sec)
residue in its sequence. Sec, the 21st naturally occurring genetically encoded amino acid …

Selenocysteine, the selenium‐containing analogue of cysteine, is the twenty‐first
proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in …

The synthesis of proteins with a fully native sequence is an ongoing challenge in protein
chemistry. Native chemical ligation (NCL) approaches have proven to be generally …

Significance: Among trace elements used as cofactors in enzymes, selenium is unique in
that it is incorporated into proteins co-translationally in the form of an amino acid …

The reaction mechanism of the GPx-like oxidation of PhSH with H2O2 catalyzed by
selenoxides proceeds via formation of the hydroxy perhydroxy selenane, which is a stronger …

Cysteamine reduces selenocystamine to form hemiselenocystamine and then cystamine.
The rate constants are k 1= 1.3× 105 M− 1 s− 1; k− 1= 2.6× 107 M− 1 s− 1; k 2= 11 M− 1 s …