DNA/cationic lipid (lipoplexes), DNA/cationic polymer (polyplexes) and DNA/cationic
polymer/cationic lipid (lipopolyplexes) electrostatic complexes are proposed as non‐viral …

Cationic lipids are one of the most widely used nonviral vectors for gene delivery and are
especially attractive because they can be easily synthesized and extensively characterized …

Liposomes are delivery systems that have been used to formulate a vast variety of
therapeutic and imaging agents for the past several decades. They have significant …

We report the preparation of mannosylated nanoparticles loaded with messenger RNA
(mRNA) that enhance the transfection of dendritic cells (DCs) in vivo and the anti-B16F10 …

In vitro transcribed mRNA constitutes a versatile platform to encode antigens and to evoke
CD8 T-cell responses. Systemic delivery of mRNA packaged into cationic liposomes …

Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …

Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens
demonstrated safety and induction of tumor-specific immune responses. Their proper …

This feature article describes the recent developments in the design of cationic lipids and
their applications in gene delivery. Various structure–activity investigations explaining the …

The effects of lipid compositions on their physicochemical properties and transfection
efficiencies were investigated. Four liposome formulations with different 1, 2-dioleoyl-3 …

Over the last several years, various gene delivery systems have been developed for gene
therapy applications. Although viral vector-based gene therapy has led to the greatest …