Adult Leydig cells develop from undifferentiated mesenchymal-like stem cells (stem Leydig
cells, SLCs) present in the interstitial compartment of the early postnatal testis. Putative …

The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins
acting as ligand-activated transcription factors. Functionally, NRs are essential in …

Background Platinum‐based chemotherapy is effective in inducing shrinkage of primary
lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from …

Oxytocin has been used for many years in obstetric practice for the induction and
augmentation of labour, and for the prevention of postpartum haemorrhage (Zeeman et al …

Atria and ventricles exhibit distinct molecular profiles that produce structural and functional
differences between the two cardiac compartments. However, the factors that determine …

The incidence of osteoporosis is high in postmenopausal women due to altered estrogen
levels and continuous calcium loss that occurs with aging. Recent studies have shown that …

A major clinical hurdle for the management of advanced prostate cancer (PCa) in patients is
the resistance of tumors to androgen deprivation therapy (ADT) and their subsequent …

Osteoblasts and adipocytes are differentiated from common mesenchymal stem cells
(MSCs) in processes which are tightly controlled by various growth factors, signaling …

Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells, have been
isolated from various adult tissue sources because of their capabilities of differentiating into …

Human pluripotent stem cells (hPSCs) are widely used to study cardiovascular cell
differentiation and function. Here, we induced differentiation of hPSCs (both embryonic and …