Genomic imprinting disorders: lessons on how genome, epigenome and environment interact

D Monk, DJG Mackay, T Eggermann, ER Maher… - Nature Reviews …, 2019 - nature.com
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

Non-coding RNAs as drug targets

M Matsui, DR Corey - Nature reviews Drug discovery, 2017 - nature.com
Most of the human genome encodes RNAs that do not code for proteins. These non-coding
RNAs (ncRNAs) may affect normal gene expression and disease progression, making them …

Cerebral plasticity: Windows of opportunity in the developing brain

FY Ismail, A Fatemi, MV Johnston - European journal of paediatric …, 2017 - Elsevier
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …

Consciousness among delta waves: a paradox?

J Frohlich, D Toker, MM Monti - Brain, 2021 - academic.oup.com
A common observation in EEG research is that consciousness vanishes with the
appearance of delta (1–4 Hz) waves, particularly when those waves are high amplitude …

Self-domestication in Homo sapiens: Insights from comparative genomics

C Theofanopoulou, S Gastaldon, T O'Rourke… - PloS one, 2017 - journals.plos.org
This study identifies and analyzes statistically significant overlaps between selective sweep
screens in anatomically modern humans and several domesticated species. The results …

Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci

T Eggermann, G Perez de Nanclares, ER Maher… - Clinical …, 2015 - Springer
Congenital imprinting disorders (IDs) are characterised by molecular changes affecting
imprinted chromosomal regions and genes, ie genes that are expressed in a parent-of-origin …

Sleep in children with neurodevelopmental disabilities

M Angriman, B Caravale, L Novelli, R Ferri… - …, 2015 - thieme-connect.com
This review describes recent research in pediatric sleep disorders associated with
neurodevelopmental disabilities (NDDs) and their treatment. NDDs affect more than 2% of …

Mouse and rat ultrasonic vocalizations in neuroscience and neuropharmacology: State of the art and future applications

M Premoli, S Pietropaolo, M Wöhr… - European Journal of …, 2023 - Wiley Online Library
Mice and rats emit ultrasonic vocalizations (USVs), which may express their arousal and
emotional states, to communicate with each other. There is continued scientific effort to …

[HTML][HTML] Angelman syndrome

SS Margolis, GL Sell, MA Zbinden, LM Bird - Neurotherapeutics, 2015 - Elsevier
In this review we summarize the clinical and genetic aspects of Angelman syndrome (AS), its
molecular and cellular underpinnings, and current treatment strategies. AS is a …

Protein phosphatase 2A–structure, function and role in neurodevelopmental disorders

P Sandal, CJ Jong, RA Merrill, J Song… - Journal of cell …, 2021 - journals.biologists.com
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …