The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

Background Multiple sclerosis is an acquired demyelinating disease of the central nervous
system. It is the second most common cause of disability in adults in United States after head …

Background Tolebrutinib is an oral, CNS-penetrant, irreversible inhibitor of Bruton's tyrosine
kinase, an enzyme expressed in B lymphocytes and myeloid cells including microglia, which …

The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …

The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

In multiple sclerosis and the experimental autoimmune encephalitis (EAE) mouse model,
two pools of morphologically indistinguishable phagocytic cells, microglia and inflammatory …

While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

There is a broad consensus that multiple sclerosis (MS) represents more than an
inflammatory disease: it harbors several characteristic aspects of a classical …

Objective To use the large dataset from the Tysabri Outreach: Unified Commitment to Health
(TOUCH) program to compare progressive multifocal leukoencephalopathy (PML) risk with …