Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …

Epigenetic modifications of the nuclear genome, including DNA methylation, histone
modifications and non-coding RNA post-transcriptional regulation, are increasingly being …

Mitochondria are subcellular organelles involved in essential cellular functions, including
cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They …

Epigenetic alterations, along with genetic alterations, have long been regarded as the most
important mechanism participating in carcinogenesis. DNA methylation, histone …

Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …

Background & aims B-vitamins and homocysteine may contribute to the development of
gestational diabetes mellitus (GDM), but existing studies are inconsistent. We examined the …

Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …