A wound is an interruption of the normal anatomic structure and function of the skin, which is
critical in protecting against foreign pathogens, regulating body temperature and water …

Deferoxamine (DFO) is an iron chelator with FDA approval for the clinical treatment of iron
excess. As a well-established stabilizer of hypoxia-inducible factor-1α (HIF-1α), DFO can …

Chronic wound, such as skin defect after burn, pressure ulcer, and diabetic foot ulcer is very
difficult to cure. Its pathological process is often accompanied with local temperature rise, pH …

Diabetic ulcer is a serious complication of diabetes. Compared with that of healthy people,
the skin of patients with a diabetic ulcer is more easily damaged and difficult to heal. Without …

Wound healing is a complex physiological process involving various cell types and
signaling pathways. The capability to observe the dynamics of wound repair offers valuable …

There is undisputable benefit in translating basic science research concretely into clinical
practice, and yet, the vast majority of therapies and treatments fail to achieve approval. The …

Ionizing radiation has been pivotal in cancer therapy since its discovery. Despite its
therapeutic benefits, IR causes significant acute and chronic complications due to DNA …

While wound healing in humans occurs primarily through re-epithelization, in rodents it also
occurs through contraction of the panniculus carnosus, an underlying muscle layer that …

Neoadjuvant radiotherapy (NAC), a preoperative intervention regimen for reducing the stage
of primary tumors and surgical margins, has gained increasing attention in the past decade …

Wound dehiscence, oftentimes a result of the poor tensile strength of early healing wounds,
is a significant threat to the post‐operative patient, potentially causing life‐threatening …