The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …

The enhanced permeability and retention (EPR) of nanoparticles in tumors has long stood
as one of the fundamental principles of cancer drug delivery, holding the promise of safe …

Recent advances in nanotechnology have offered new hope for cancer detection,
prevention, and treatment. While the enhanced permeability and retention effect has served …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Simple Summary One of the important efforts in the treatment of cancers is to achieve
targeted drug delivery by nanocarriers to be more effective and reduce adverse effects …

Recent advances in nanoparticle technology have enabled the fabrication of nanoparticle
classes with unique sizes, shapes and materials, which in turn has facilitated major …

Extracellular vesicles (EVs) are membrane-derived particles surrounded by a (phospho)
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …

To be most effective anticancer drugs must penetrate tissue efficiently, reaching all the
cancer cells that comprise the target population in a concentration sufficient to exert a …

The justification of cancer nanomedicine relies on enhanced permeation (EP) and retention
(R) effect and the capability of intracellular targeting due primarily to size after internalization …

Leakiness of blood vessels in tumors may contribute to disease progression and is key to
certain forms of cancer therapy, but the structural basis of the leakiness is unclear. We …