Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure

MP Shakarjian, DE Heck, JP Gray, PJ Sinko… - Toxicological …, 2010 - academic.oup.com
Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin,
eyes, and lung. It remains a significant military and civilian threat. The characteristic …

Oxidants and antioxidants in sulfur mustard–induced injury

JD Laskin, AT Black, YH Jan, PJ Sinko… - Annals of the New …, 2010 - Wiley Online Library
Sulfur mustard (SM) is a chemical weapon that targets the skin, eyes, and lung. It was first
employed during World War I and it remains a significant military and civilian threat. As a …

IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production

X Teng, Z Hu, X Wei, Z Wang, T Guan, N Liu… - The Journal of …, 2014 - journals.aai.org
IL-37 is a potent inhibitor of innate immunity by shifting the cytokine equilibrium away from
excessive inflammation. Psoriasis is thought to be initiated by abnormal interactions …

Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries

SNS Anumolu, AR Menjoge, M Deshmukh, D Gerecke… - Biomaterials, 2011 - Elsevier
Doxycycline hydrogels containing reversible disulfide crosslinks were investigated for a
dermal wound healing application. Nitrogen mustard (NM) was used as a surrogate to mimic …

Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and …

D Kumar, N Tewari-Singh, C Agarwal, AK Jain, S Inturi… - Toxicology letters, 2015 - Elsevier
Our recent studies in SKH-1 hairless mice have demonstrated that topical exposure to
nitrogen mustard (NM), an analog of sulfur mustard (SM), triggers the inflammatory …

Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissues through activation of cannabinoid CB 2 receptors

TF Su, YQ Zhao, LH Zhang, M Peng… - … Journal of Pain, 2012 - Wiley Online Library
Endogenous cannabinoids and peripheral cannabinoid CB2 receptors (CB2Rs) are
involved in the antinociceptive effect of electroacupuncture (EA) on inflammatory pain …

Doxycycline loaded poly (ethylene glycol) hydrogels for healing vesicant-induced ocular wounds

SNS Anumolu, AS DeSantis, AR Menjoge, RA Hahn… - Biomaterials, 2010 - Elsevier
Half mustard (CEES) and nitrogen mustard (NM) are commonly used surrogates and
vesicant analogs of the chemical warfare agent sulfur mustard. In the current study, in situ …

MG53 mitigates nitrogen mustard-induced skin injury

H Li, Z Li, X Li, C Cai, SL Zhao, RE Merritt, X Zhou… - Cells, 2023 - mdpi.com
Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury
and blistering through complicated cellular events, involving DNA damage, free radical …

Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice

A Pal, N Tewari-Singh, M Gu, C Agarwal… - Free Radical Biology …, 2009 - Elsevier
A monofunctional analog of the chemical warfare agent sulfur mustard (HD), 2-chloroethyl
ethyl sulfide (CEES), induces tissue damage similar to HD. Herein we studied the molecular …

Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation

N Tewari-Singh, AK Jain, S Inturi, C Agarwal, CW White… - 2012 - journals.plos.org
Chemical warfare agent sulfur mustard (HD) inflicts delayed blistering and incapacitating
skin injuries. To identify effective countermeasures against HD-induced skin injuries, efficacy …