Comorbidities and the impact of atopic dermatitis

JI Silverberg - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with
substantial patient and population burdens. A number of comorbid health problems occur in …

Association between atopic dermatitis, depression, and suicidal ideation: a systematic review and meta-analysis

KR Patel, S Immaneni, V Singam, S Rastogi… - Journal of the American …, 2019 - Elsevier
Background Atopic dermatitis (AD) is associated with psychologic distress. However,
previous studies found conflicting results about whether AD is associated with increased …

Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: a randomized clinical trial

JI Silverberg, EL Simpson, JP Thyssen… - JAMA …, 2020 - jamanetwork.com
Importance Abrocitinib, an oral, once-daily Janus kinase 1 selective inhibitor, was effective
and well tolerated in a phase 3 monotherapy trial of patients with moderate-to-severe atopic …

[HTML][HTML] Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study

JI Silverberg, JM Gelfand, DJ Margolis… - Annals of Allergy …, 2018 - Elsevier
Background The patient burden and quality of life (QOL) impact of atopic dermatitis (AD) in
the United States population is not well established. Objective To elucidate the patient …

Efficacy and safety of baricitinib combined with topical corticosteroids for treatment of moderate to severe atopic dermatitis: a randomized clinical trial

K Reich, K Kabashima, K Peris, JI Silverberg… - JAMA …, 2020 - jamanetwork.com
Importance Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced
disease severity in moderate to severe atopic dermatitis (AD) in 2 phase 3 monotherapy …

Integrated safety analysis of abrocitinib for the treatment of moderate-to-severe atopic dermatitis from the phase II and phase III clinical trial program

EL Simpson, JI Silverberg, A Nosbaum… - American journal of …, 2021 - Springer
Background Pivotal phase III studies demonstrated that abrocitinib, an oral, once-daily, JAK1-
selective inhibitor, is effective treatment for moderate-to-severe atopic dermatitis (AD) as …

Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape

M Boguniewicz, L Fonacier, E Guttman-Yassky… - Annals of Allergy …, 2018 - Elsevier
The implementation of treatment guidelines for atopic dermatitis is challenging, in part
because of different guidance documents being used by different groups of specialists and …

Efficacy and safety of lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis: a randomized …

EL Simpson, M Gooderham, A Wollenberg… - JAMA …, 2023 - jamanetwork.com
Importance Lebrikizumab (LEB), a high-affinity monoclonal antibody targeting interleukin (IL)-
13, demonstrated efficacy and safety in patients with moderate-to-severe atopic dermatitis …

Symptoms and diagnosis of anxiety and depression in atopic dermatitis in US adults

JI Silverberg, JM Gelfand, DJ Margolis… - British Journal of …, 2019 - academic.oup.com
Background The relationship between atopic dermatitis (AD), anxiety and depression in the
US adult population is not well established. Objectives To determine the relationship of AD …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …