Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …

Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking,
are major lung diseases affecting millions of individuals worldwide. The generated gas …

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …

Abstract Angiotensin-converting enzyme 2 (ACE2) is the binding-site and entry-point for
SARS-CoV-2 in human and highly expressed in the lung. Cigarette smoking (CS) is the …

Cardiovascular comorbidities are pervasive in chronic obstructive pulmonary disease
(COPD) and often result in serious adverse cardiovascular events. Tongxinluo (TXL) has …

While breathing, many microorganisms, harmful environmental particles, allergens, and
environmental pollutants enter the human airways. The human respiratory tract is lined with …

Both particulate matter and gaseous components of air pollution have already been shown
to increase cardiovascular mortality in numerous studies. It is, however, important to note …

Methods PubMed database was searched to look for relevant articles. Inclusion criteria were
as follows:(1) cohort studies or case series studies;(2) study population included individuals …

Inflammasomes are multiprotein complexes tasked with sensing endogenous or exogenous
inflammatory signals and integrating this signal into a downstream response. Inflammasome …

Naringin is one of the natural flavonoids extracted from many Chinese medicines. It
ameliorates endothelial dysfunctions in atherosclerosis, diabetes, and cardiovascular …