The study of antiviral pathways to reveal methods for the effective response and clearance of
virus is closely related to understanding interferon (IFN) signaling and its downstream target …

The innate immune system is a broad collection of critical intra‐and extra‐cellular processes
that limit the infectivity of diverse pathogens. The 2′‐5′‐oligoadenylate synthetase (OAS) …

Zinc finger antiviral protein (ZAP) is a powerful restriction factor for viruses with elevated
CpG dinucleotide frequencies. We report that ZAP similarly mediates antiviral restriction …

Dengue virus (DENV) is an emerging mosquito-borne human pathogen that affects millions
of individuals each year by causing severe and potentially fatal syndromes. Despite intense …

Mast cell products and high levels of type 2 cytokines are associated with severe dengue
disease. Group 2 innate lymphoid cells (ILC2) are type-2 cytokine-producing cells that are …

The arthropod-borne diseases caused by dengue virus (DENV) are a major and emerging
problem of public health worldwide. Infection with DENV causes a series of clinical …

Early detection of infection is a central and critical component of our innate immune system.
Mammalian cells have developed specialized receptors that detect RNA with unusual …

Abstract Upon viral infection, the 2′, 5′-oligoadenylate synthetase (OAS)-ribonuclease L
(RNaseL) system works to cleave viral RNA, thereby blocking viral replication. However, it is …

It has been well-recognized that inflammation alongside tissue repair and damage
maintaining tissue homeostasis determines the initiation and progression of complex …

Background Vaccine development for influenza A/H5N1 is an important public health
priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines …