Multiplexed imaging in oncology

C Andreou, R Weissleder, MF Kircher - Nature Biomedical Engineering, 2022 - nature.com
In oncology, technologies for clinical molecular imaging are used to diagnose patients,
establish the efficacy of treatments and monitor the recurrence of disease. Multiplexed …

Targeted radionuclide therapy of prostate cancer—from basic research to clinical perspectives

M Czerwińska, A Bilewicz, M Kruszewski… - Molecules, 2020 - mdpi.com
Prostate cancer is the most commonly diagnosed malignancy in men and the second
leading cause of cancer-related deaths in Western civilization. Although localized prostate …

De novo approaches to the solid-phase separation of Titanium (IV) and Scandium (III): translating speciation data to selective on-bead chelation toward applications in …

AJ Koller, L Wang, M Deluca, O Glaser… - Inorganic …, 2023 - ACS Publications
The solution chemistry of the hydrolytic, early-transition-metal ions Ti4+ and Sc3+ represents
a coordination chemistry challenge with important real-world implications, specifically in the …

Design strategies and medicinal applications of metal-peptidic bioconjugates

SM Meier-Menches, A Casini - Bioconjugate Chemistry, 2020 - ACS Publications
The conjugation of metal-based scaffolds to peptides, proteins, or antibodies allows the
systemic targeting of these payloads to specific locations in the body, such as target …

[HTML][HTML] Advances in surface enhanced Raman spectroscopy for in vivo imaging in oncology

F Nicolson, L Clark, SR Panikkanvalappil… - …, 2022 - ncbi.nlm.nih.gov
In the last two decades, the application of surface enhanced Raman scattering (SERS)
nanoparticles for preclinical cancer imaging has attracted increasing attention. Raman …

Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis

X Liu, Z Ren, C Tan, FL Núñez-Santana, ME Kelly… - The Journal of Clinical …, 2024 - jci.org
A major limitation of immunotherapy is the development of resistance resulting from cancer-
mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical …

Atomic nanogenerators in targeted alpha therapies: Curie's legacy in modern cancer management

M Roscher, G Bakos, M Benešová - Pharmaceuticals, 2020 - mdpi.com
Atomic in vivo nanogenerators such as actinium-225, thorium-227, and radium-223 are of
increasing interest and importance in the treatment of patients with metastatic cancer …

Implementing Ac-225 labelled radiopharmaceuticals: practical considerations and (pre-) clinical perspectives

EL Hooijman, V Radchenko, SW Ling… - EJNMMI …, 2024 - Springer
Background In the past years, there has been a notable increase in interest regarding
targeted alpha therapy using Ac-225, driven by the observed promising clinical anti-tumor …

Recent advances and impending challenges for the radiopharmaceutical sciences in oncology

SE Lapi, PJH Scott, AM Scott, AD Windhorst… - The Lancet …, 2024 - thelancet.com
This paper is the first of a Series on theranostics that summarises the current landscape of
the radiopharmaceutical sciences as they pertain to oncology. In this Series paper, we …

Optimizing the Safety and Efficacy of Bio-Radiopharmaceuticals for Cancer Therapy

CN Funeh, J Bridoux, T Ertveldt, TWM De Groof… - Pharmaceutics, 2023 - mdpi.com
The precise delivery of cytotoxic radiation to cancer cells through the combination of a
specific targeting vector with a radionuclide for targeted radionuclide therapy (TRT) has …