RNA drugs and RNA targets for small molecules: principles, progress, and challenges
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …
The current state and future directions of RNAi-based therapeutics
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …
Reexamining assumptions about miRNA-guided gene silencing
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …
regulate the expression of any RNA. This potential has led to the publication of several …
Structure of the human DICER–pre-miRNA complex in a dicing state
Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …
Synthetic lethality and cancer
A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …
alone is viable but the perturbation of both genes simultaneously results in the loss of …
Signal transducer and activator of transcription (STATs) proteins in cancer and inflammation: functions and therapeutic implication
Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …
with Janus kinases (JAK) family protein and capable of integrating inputs from different …
Bioinspired Spatiotemporal Management toward RNA Therapies
Ribonucleic acid (RNA)-based therapies have become an attractive topic in disease
intervention, especially with some that have been approved by the FDA such as the mRNA …
intervention, especially with some that have been approved by the FDA such as the mRNA …
Liposome-based drug co-delivery systems in cancer cells
Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
Small-molecule modulation of protein homeostasis
GM Burslem, CM Crews - Chemical reviews, 2017 - ACS Publications
Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …
research tool but lacks the advantages of small molecules with respect to cell permeability …
Rationally designed molecular beacons for bioanalytical and biomedical applications
J Zheng, R Yang, M Shi, C Wu, X Fang, Y Li… - Chemical Society …, 2015 - pubs.rsc.org
Nucleic acids hold promise as biomolecules for future applications in biomedicine and
biotechnology. Their well-defined structures and compositions afford unique chemical …
biotechnology. Their well-defined structures and compositions afford unique chemical …