The PTPN22 locus is one of the strongest risk factors outside of the major histocompatability
complex that associates with autoimmune diseases. PTPN22 encodes lymphoid protein …

Reversible tyrosine phosphorylation of proteins is a key regulatory mechanism for numerous
important aspects of eukaryotic physiology and is catalysed by kinases and phosphatases …

Membrane-shaping proteins of the BAR domain superfamily are determinants of organelle
biogenesis, membrane trafficking, cell division, and cell migration. An upsurge of research …

Pyrin, the familial Mediterranean fever protein, is found in association with the cytoskeleton
in myeloid/monocytic cells and modulates IL-1β processing, NF-κB activation, and …

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne, OMIM#
604416) and familial recurrent arthritis (FRA) are rare inherited disorders of early onset …

BAR and ENTH domains are families of α-helical lipid bilayer binding modules found in
proteins that function in endocytosis, actin regulation and signaling. Several members of …

The conserved FER-CIP4 homology (FCH) domain is found in the pombe Cdc15 homology
(PCH) protein family members, including formin-binding protein 17 (FBP17). However, the …

The molecular mechanism by which mutations in the cytoskeleton-organizing protein
PSTPIP1 cause the autoinflammatory PAPA syndrome is still elusive. Here, we demonstrate …

It is now well established that the members of the PTP (protein tyrosine phosphatase)
superfamily play critical roles in fundamental biological processes. Although there has been …

Phagocytosis is the uptake of large particles by cells by a mechanism that is based on local
rearrangement of the actin microfilament cytoskeleton. In higher organisms, phagocytic cells …