Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic
filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must …

During interphase, filamentous actin, microtubules, and intermediate filaments regulate cell
shape, motility, transport, and interactions with the environment. These activities rely on …

Actin isoforms organize into distinct networks that are essential for the normal function of
eukaryotic cells. Despite a high level of sequence and structure conservation, subtle …

The disruption of the protective intestinal barrier—the 'leaky gut'—is a common complication
of the inflammatory bowel disease. There is limited data on the mechanisms of the intestinal …

Cysteine residues can undergo multiple posttranslational modifications with diverse
functional consequences, potentially behaving as tunable sensors. The intermediate …

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical,
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …

Numerous cellular functions depend on actin filament (F-actin) disassembly. The best-
characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded …

The actin cytoskeleton of eukaryotic cells is a dynamic, fibrous network that is regulated by
the concerted action of actin-binding proteins (ABPs). In particular, rapid polarization of cells …

Life-long eye lens function requires an appropriate gradient refractive index, biomechanical
integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1 …

Actin and its dynamic structural remodelings are involved in multiple cellular functions,
including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle …