Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is
packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission …

We discuss here the variety of approaches that have been taken to inhibit different forms of
endocytosis. Typically, both non-specific and specific chemical inhibitors of endocytosis are …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly
sorted to lysosomal degradation through several endocytic pathways. Defective vesicular …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Nerves enable cancer progression, as cancers have been shown to extend along nerves
through the process of perineural invasion, which carries a poor prognosis. Furthermore, the …

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

The polarized distribution of functions in polarized cells requires the coordinated interaction
of three machineries that modify the basic mechanisms of intracellular protein trafficking and …