Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

Abstract E1, an ATP-dependent DNA helicase, is the only enzyme encoded by
papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in …

Secretion of interferons (IFNs) from virus-infected cells is a hallmark of host antiviral
immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral …

The interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of antiviral
proteins conserved throughout all vertebrates. IFIT1 binds tightly to non-self RNA …

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are highly expressed during
the cell-intrinsic immune response to viral infection. IFIT1 inhibits translation by binding …

Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis;
however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate …

Birds have a smaller repertoire of immune genes than mammals. In our efforts to study
antiviral responses to influenza in avian hosts, we have noted key genes that appear to be …

Hepatitis C virus (HCV) often leads to persistent infection. Interferon (IFN) and IFN-
stimulated genes (ISGs) are amplified during HCV infection but fail to eliminate virus from …

Interferon-induced proteins with tetratricopeptide repeats (IFITs) are a family of proteins,
which are strongly induced downstream of type I interferon signaling. The molecular …

The critical role of interferons (IFNs) in mediating the innate immune response to
cytomegalovirus (CMV) infection is well established. However, in recent years the functional …