Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

Two-photon microscopy has enabled high-resolution imaging of neuroactivity at depth within
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …

Since the introduction of calcium imaging to monitor neuronal activity with single-cell
resolution, optical imaging methods have revolutionized neuroscience by enabling …

The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

Activity in striatal direct-and indirect-pathway spiny projection neurons (SPNs) is critical for
proper movement. However, little is known about the spatiotemporal organization of this …

Efforts to scale neuroimaging towards the direct visualization of mammalian brain-wide
neuronal activity have faced major challenges. Although high-resolution optical imaging of …

The simple and compact optics of lensless microscopes and the associated computational
algorithms allow for large fields of view and the refocusing of the captured images. However …

A detailed understanding of the function of neural networks and how they are supported by a
dynamic vascular system requires fast three-dimensional imaging in thick tissues. Here we …