Poloxamers, also called Pluronic, belong to a unique class of synthetic tri-block copolymers
containing central hydrophobic chains of poly (propylene oxide) sandwiched between two …

Nanotechnology in medical applications, especially in oncology as drug delivery systems,
has recently shown promising results. However, although these advances have been …

We investigated the effect of ultrasound-assisted pH shift treatment on the micro-particle,
molecular, and spatial structure of rapeseed protein isolates (RPI). Various ultrasonic …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Zeta potential is a scientific term for electrokinetic potential in colloidal systems which has a
major effect on the various properties of nano-drug delivery systems. Presently, colloidal …

Many approaches have been developed over time to overcome the bioavailability limitations
of poorly soluble drugs. With the advances in nanotechnology in recent decades, science …

Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting
approach for poorly soluble drugs. Nanocrystals provide special features including …

As nano-sizing is becoming a more common approach for pharmaceutical product
development, researchers are taking advantage of the unique inherent properties of …

The solubility dependent bioavailability problem has become a major hurdle in drug
development processes. Drug nanocrystals have been widely accepted by the …

Drug nanoparticles embedded in a dispersant matrix as a secondary phase, ie, drug-laden
nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and …