Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Due to their rapid and widespread development, DNA vaccines have entered into a variety
of human clinical trials for vaccines against various diseases including cancer. Evidence that …

Gut mucosal barrier breakdown and inflammation have been associated with high levels of
flagellin, the principal bacterial flagellar protein. Although several gut commensals can …

Multidrug-resistant Pseudomonas aeruginosa is one of the worldwide health problems
involved in elevated mortality and morbidity. Therefore, it is important to find a therapeutic for …

DNA vaccination has been of great interest since its discovery in the 1990s due to its ability
to elicit both humoral and cellular immune responses. DNA vaccines consist of a DNA …

Infections caused by multidrug-resistant Gram-negative bacteria have emerged as a major
threat to public health worldwide. The high mortality and prevalence, along with the slow …

Pseudomonas aeruginosa is a serious pathogen in hospitalized, immunocompromised, and
cystic fibrosis (CF) patients. P. aeruginosa is motile via a single polar flagellum made of …

Infections with Pseudomonas aeruginosa are a major health problem for immune-
compromised patients and individuals with cystic fibrosis. A vaccine against P. aeruginosa …

Background Ileal lesions in Crohn's disease patients are colonized by pathogenic adherent-
invasive Escherichia coli (AIEC) that harbor various virulence factors involved in adhesion to …

TLRs trigger immunity by detecting microbe-associated molecular patterns (MAMPs).
Flagellin is a unique MAMP because it harbors 1) an antigenic hypervariable region and 2) …