Chromosome organization in early meiotic prophase
C Grey, B De Massy - Frontiers in cell and developmental biology, 2021 - frontiersin.org
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …
Genome management and mismanagement—cell-level opportunities and challenges of whole-genome duplication
L Yant, K Bomblies - Genes & development, 2015 - genesdev.cshlp.org
Whole-genome duplication (WGD) doubles the DNA content in the nucleus and leads to
polyploidy. In whole-organism polyploids, WGD has been implicated in adaptability and the …
polyploidy. In whole-organism polyploids, WGD has been implicated in adaptability and the …
Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1
In budding yeast the pachytene checkpoint 2 (Pch2) protein regulates meiotic chromosome
axis structure by maintaining the domain-like organization of the synaptonemal complex …
axis structure by maintaining the domain-like organization of the synaptonemal complex …
Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes
AF Severson, BJ Meyer - Elife, 2014 - elifesciences.org
We show that multiple, functionally specialized cohesin complexes mediate the
establishment and two-step release of sister chromatid cohesion that underlies the …
establishment and two-step release of sister chromatid cohesion that underlies the …
Peptide-decorated tunable-fluorescence graphene quantum dots
We report here the synthesis of graphene quantum dots with tunable size, surface chemistry,
and fluorescence properties. In the size regime 15–35 nm, these quantum dots maintain …
and fluorescence properties. In the size regime 15–35 nm, these quantum dots maintain …
The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions
K Muniyappa, R Kshirsagar, I Ghodke - Gene, 2014 - Elsevier
The HORMA domain (for Hop1p, Rev7p and MAD2) was discovered in three chromatin-
associated proteins in the budding yeast Saccharomyces cerevisiae. This domain has also …
associated proteins in the budding yeast Saccharomyces cerevisiae. This domain has also …
Probing the potential role of non-B DNA structures at yeast meiosis-specific DNA double-strand breaks
R Kshirsagar, K Khan, MV Joshi, RV Hosur… - Biophysical …, 2017 - cell.com
A plethora of evidence suggests that different types of DNA quadruplexes are widely present
in the genome of all organisms. The existence of a growing number of proteins that …
in the genome of all organisms. The existence of a growing number of proteins that …
N-Terminal Disordered Domain of Saccharomyces cerevisiae Hop1 Protein Is Dispensable for DNA Binding, Bridging, and Synapsis of Double-Stranded DNA …
The cytological architecture of the synaptonemal complex (SC), a meiosis-specific
proteinaceous structure, is evolutionarily conserved among eukaryotes. However, little is …
proteinaceous structure, is evolutionarily conserved among eukaryotes. However, little is …
Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction
N Sharadamma, Y Harshavardhana, A Ravishankar… - Biochemistry, 2015 - ACS Publications
The annotated whole-genome sequence of Mycobacterium tuberculosis indicated that
Rv1388 (Mtihf) likely encodes a putative 20 kDa integration host factor (mIHF). However …
Rv1388 (Mtihf) likely encodes a putative 20 kDa integration host factor (mIHF). However …
Saccharomyces cerevisiae Red1 protein exhibits nonhomologous DNA end–joining activity and potentiates Hop1-promoted pairing of double-stranded DNA
R Kshirsagar, I Ghodke, K Muniyappa - Journal of Biological Chemistry, 2017 - ASBMB
Elucidation of the function of synaptonemal complex (SC) in Saccharomyces cerevisiae has
mainly focused on in vivo analysis of recombination-defective meiotic mutants …
mainly focused on in vivo analysis of recombination-defective meiotic mutants …